European Skilled Membership Rugby | Stade Français search to mark return in type

Stade Français Paris is returning to Europe’s elite rugby competition for the first time since 2015/16, but was a regular quarter-finalist in the tournament’s early years – as we learn in this season’s latest analysis of the Heineken Champions Cup teams.

European Cup record

Stade Français have reached the finals twice but have been narrowly beaten each time. In 2001 they lost 34:30 to the Leicester Tigers at Parc des Princes in Paris, and four years later they put Stade Toulousain in extra time before losing 18:12 at BT Murrayfield.

Last season

The TOP 14 club never got past the pool phase of the EPCR Challenge Cup after losing their opening game 44:20 at home to Benetton Rugby.

Rugby director

Gonzalo Quesada is in charge of Stade Français in his second term, having been on the hot seat there for the first time between 2013 and 2017, when he led the Paris Club to the TOP 14 title (2015) and the EPCR Challenge Cup (2017). The former Argentine aviator had one season as sporting director at Biarritz Olympique before returning home to take on Los Jaguares, which he led to an inaugural Super Rugby final in 2019. He then returned to Stade in June 2020.

Key characters

The Stade Français squad is a multi-talented mix of French, Argentine, Australian, New Zealand, Tongan, Fijian, Samoan, Canadian and Georgian internationals, the most famous of whom are probably the French curls Yoann Maestri and Paul Gabrillagues, Argentina flies half Nicolas Sanchez and Striker Marcus Kremer in the back row.

Pool accessories

Stade Français begins its Pool B program with a trip to Connacht Rugby on December 12th and a week later it’s a home game against the Bristol Bears. Round 3 is the second leg against the English club at Ashton Gate on January 15th and Stade closes its pool games with a game against Connacht at Stade Jean Bouin on January 23rd.

Merck to hunt emergency authorization for oral Covid-19 therapy

A nurse tends to a Covid-19 patient at SSM Health St. Anthony Hospital in Oklahoma City on August 24, 2021.

Nick Oxford | Reuters

Merck and Ridgeback Biotherapeutics plan to apply for emergency approval for their oral antiviral treatment for Covid after the drug shows “compelling results” in clinical trials.

The drug molnupiravir reduced the risk of hospitalization or death in patients with mild or moderate cases of Covid by around 50%, the companies said on Friday. Molnupiravir is given orally and works by stopping the coronavirus from replicating in the body.

An interim analysis of a Phase 3 study found that 7.3% of molnupiravir-treated patients were hospitalized within 29 days. Of the patients who received a placebo, 14.1% were hospitalized or died on day 29. No deaths were reported in patients receiving molnupiravir within the 29-day period, while eight deaths were reported in placebo-treated patients.

All 775 study participants had laboratory-confirmed symptomatic Covid-19 and were randomly assigned molnupiravir or a placebo within five days of symptoms.

Each participant was unvaccinated and had at least one underlying factor that placed them at a higher risk of developing a more severe case of the virus. The most common risk factors included obesity, over 60 years of age, and diabetes or heart disease.

The phase 3 part of the study was conducted in more than 170 locations in countries such as the United States, Brazil, Italy, Japan, South Africa, Taiwan, and Guatemala.

The study showed that molnupiravir’s effectiveness was not influenced by the time when symptoms appeared or the patients’ underlying risk factors. It was also shown to be consistently effective in treating all variants of Covid, including the widely used and highly transferable delta expansion.

Side effects were similar in the molnupiravir and placebo groups, with approximately 10% reporting adverse events. Only 1.3% of the molnupiravir group discontinued therapy because of an adverse event – less than the 3.4% of the placebo group who did.

Recruitment for the study will be terminated prematurely based on the positive results on the recommendation of an independent data monitoring committee and in consultation with the US Food and Drug Administration.

Merck is also testing molnupiravir in a separate global phase 3 study to evaluate its effectiveness in preventing the spread of Covid in households.

“Profound Effect”

Robert M. Davis, CEO and President of Merck, said in a press release on Friday that the company would do everything possible to get molnupiravir to patients as soon as possible.

“With these compelling results, we are optimistic that molnupiravir can become a key drug in the global effort to fight the pandemic,” he said.

Wendy Holman, CEO of Ridgeback Biotherapeutics, added, “As the virus continues to be widespread and the therapeutic options currently available are infused or require access to a health facility, antiviral treatments can be taken at home to help people with Covid-19 from the To keep disease away hospital urgently needed. “

“We are very encouraged by the results of the interim analysis and hope that molnupiravir, if approved for use, can have a profound impact on the control of the pandemic,” she said.

Authorization to use in an emergency

Merck said Friday it plans to apply for emergency approval for the drug in the US as soon as possible. The company also plans to file regulatory filings with other international drug regulatory agencies.

If approved by regulators, molnupiravir could be the first oral antiviral drug for Covid. Currently used antiviral treatments, such as Remdesivir, are administered intravenously.

Merck has already started production of molnupiravir. The pharmaceutical giant expects to produce 10 million treatment cycles by the end of 2021 and more doses in 2022.

The company agreed earlier this year to ship approximately 1.7 million molnupiravir courses if it receives FDA emergency or full approval.

Merck has also entered into supply and purchase agreements with other governments for the drug – pending regulatory approval – and is in talks with other governments regarding the supply of molnupiravir.

The company plans to implement a tiered pricing approach based on World Bank income criteria to ensure molnupiravir is available worldwide. Merck previously announced that it had entered into non-exclusive, voluntary licensing agreements for molnupiravir with generic drug companies to facilitate access to treatment for low- and middle-income countries. Approvals or emergency approvals from the local supervisory authorities are also pending for these agreements.

Profit sharing

Ridgeback received an upfront payment from Merck as part of the company’s development of molnupiravir. The company is also eligible for contingent payments based on development and regulatory approval milestones.

Profits from the collaboration will be shared equally between Merck and Ridgeback.

Lordstown Motors new administration says it could search cash from GM

In a reversal, Lordstown Motors’ new management said the company was not that bad after all, with enough confirmed pre-orders for its electric pickup to start production this fall with enough money to go through early next year.

The sunnier outlook comes days after the company stated in a government filing that it did not have enough funds to start commercial production and has a “going concern,” a legal phrase that suggests it does may not make it.

The startup then ousted its CEO and founder Steve Burns and CFO Julio Rodriguez on Monday. An inside report Tuesday interviewed 17 people who had worked with Burns. Some portrayed him as a visionary entrepreneur and others as a salesman who bent rules and didn’t keep promises.

But during an Automotive Press Association webinar on Tuesday heard by more than 240 reporters, Lordstown Motors’ new CEO and Independent Director Angela Strand said it was “a new day at Lordstown Motors and there will be no disruption to day-to-day operations . “

Lordstown Motors’ president, Rich Schmidt, who runs day-to-day operations, said the automaker was ready to begin building the endurance pickup in September. Around 15,000 pickups will be built by May 2022.

“We currently have enough funds to get us through the fourth quarter by May 2022,” said Schmidt. He said the company had $ 400 million “in the bank”.

But to grow it will need more funding and ask General Motors, an early investor in Lordstown Motors, for additional capital, Schmidt said.

GM is ready to listen

Lordstown Motors bought its northeast Ohio plant and equipment from GM in 2019 after GM closed the former Lordstown assembly plant.

“We have a good working relationship with GM,” said Schmidt. “We’ll talk to our original investors first, but that’s not our only option. We’ll raise the funds because we need money after May.”

GM owns approximately 5% of Lordstown Motors or approximately 7.5 million Class A common shares in exchange for an equity value of $ 75 million in the company.

GM’s equity stake primarily reflects the selling price of the plant, equipment and the value of the in-kind contributions GM has provided to help Lordstown Motors complete the purchase and bring it to market.

Despite all of Lordstown Motors’ recent troubles, GM has kept its stake, including a $ 125 million loss in the first quarter and an ongoing investigation by the Securities and Exchange Commission into research firm Hindenburg that labeled Lordstown’s vehicle pre-order claim as largely fictitious. Raise capital and give legitimacy. “

When asked if GM would be willing to invest more capital in the startup, GM spokesman Jim Cain said: “We are happy with our current relationship with Lordstown Motors and have no plans to change it, but we are ready to move on Suggestions to hear the sense of bot. “

GM facilities

Schmidt has been with Lordstown Motors since November 2019, around the time the company bought GM’s 6.2 million square meter factory.

Schmidt, an automotive veteran who has worked at Toyota, Nissan, Hyundai, Volkswagen, JD Power, and Tesla Motors, said Lordstown Motors is now actively raising money but did not provide details.

The interior of the Lordstown Motors plant in Lordstown, Ohio.  It will be converted in order to build the fully electric endurance pickup from 2021.

In November 2019, Lordstown Motors commissioned Cleveland investment bank Brown Gibbons Lang & Co. to raise $ 450 million to convert the plant.

By May 2022, Schmidt expects Lordstown Motors to have $ 25 to 50 million in cash. He said he was confident that once endurance production begins later this year, investors will see that the company “has great growth opportunities”.

On the one hand, the start-up costs were reduced by the fact that many of the former GM devices could be used in the factory, said Schmidt.

  • GM’s body shop used to manufacture the Chevrolet Cruze small car is suitable for Endurance. A new body shop would have cost $ 500 million.
  • GM’s paint shop only needed $ 14 million to convert, and it would cost $ 300 million to build a new paint shop.
  • GM built a new assembly line in 2016, a new assembly line would have cost $ 5.5 million.

Schmidt said the company has contracts with suppliers that set different costs for raw materials, although some materials like steel have increased in price. Most of the Endurance is made of aluminum, but the company has increased the starting price of the Endurance by $ 2,500 to $ 55,000.

Endurance Alpha, Lordstown Motors' first running version of the electric light pickup truck outside of the company's Detroit Engineering Center.

The Lordstown Motors plant is largely complete, said Schmidt. The automaker will start programming its paint shop this week and will build the line for installing the hub motors in July. The Endurance is powered by four motors in the hub of each wheel.

Some investors criticized the durability of the hub motors and urged Lordstown Motors to abandon the idea, but chief engineer Darren Post, who worked for GM for three decades, said, “We’re sticking with the hub motors. They are long-lasting and they are and are powerful.”

A union shop?

But the company has changed when it comes to unionizing the workforce.

About this time last year Burns told the Free Press that the work employ 4,000 to 5,000 people one day, as the case may be on request for the endurance. At the time, Burns said he would allow the UAW to organize if workers opted to unionize.

The jobs are reported to cost about $ 17 an hour, a few dollars less than what a new line worker at the Detroit Three pays per hour in the UAW’s current contract. Burns did not want to confirm a salary figure at the time.

According to Schmidt, Lordstown Motors currently employs 600 people, 130 of whom work at its development center in Farmington Hills and a few dozen in California.

When asked if Schmidt and Strand, as Burns said, were open to a union organizing campaign, Schmidt said: “We have no position on it. That is more of a question for our employees.”

He said the team is creating a culture where employees “feel like family” and the company is currently offering free breakfast and lunch. The employees also participate in the company’s success.

Schmidt said the company executives had an “unofficial off-site meeting” with the UAW “just to go over the process,” but there were no other active discussions.

In response to Schmidt’s comments, UAW Vice President Cindy Estrada, director of the UAW Organizing Division, said, “We agree with President Biden that we can build better. Building better means we can protect the environment while providing well-paid union jobs. We are disappointed that the company appears to be more interested in non-union than in working with the UAW and other stakeholders to make the company successful. “

But Schmidt said employee morale was good despite the management restructuring, poor first quarter, and other issues.

More:Fully electric pickup catches fire in Michigan – and experts warn it could happen again

More:Lordstown Motors, accused of falsifying electric vehicle orders, is facing an SEC investigation, reports said

“We’re on the same path that the former CEO suggested … the same schedule, the same marketing plan … we just have to go a little faster and make decisions a little smoother,” said Schmidt.

More:UAW stands ready to fight GM to unionize 2 new battery plants

More:Lordstown Motors, a GM investment, announces CEO and CFO resignation in major restructuring

Contact Jamie L. LaReau at 313-222-2149 or jlareau@freepress.com. Follow her on Twitter @jlareauan. Read more on General Motors and sign up for ours Auto newsletter. Become a subscriber.

High US regulators pledge to hunt reforms for cash markets

Top regulators promise to press ahead with reforms in a key corner of U.S. financial markets that the Federal Reserve and Treasury Department hurried after they were churned during the coronavirus outbreak in Spring 2020

June 11, 2021, 11:28 pm

3 minutes read

Members of the Financial Stability Oversight Council discussed reforms targeting so-called short-term finance markets, which include trillions of dollars in money market mutual funds.

The board of directors is an inter-agency group led by Treasury Secretary Janet Yellen who said the 2020 crisis prompted “extreme political intervention” by the Federal Reserve and the Treasury Department to restore order to the market.

Federal Reserve Chairman Jerome Powell, also a member of the council, said the 2020 crisis was triggered by a “jump in cash” that prompted the Fed to step in with reserve funding to calm the turmoil.

“Rapid repayments on money market funds resulted from the liquidity pressure and exacerbated it in turn,” he told the panel.

Powell said that after the Fed created a money market mutual funds liquidity facility with $ 10 billion in assistance from the Treasury Department, “the turmoil has eased, conditions in short-term finance markets have improved and access to credit has improved.”

The council received a closed briefing from staff at the Securities and Exchange Commission on the comments they had gathered on the reforms that need to be pursued to make short-term finance markets more resilient in times of financial crisis.

SEC Chairman Gary Gensler told the group during its open meeting that he had directed SEC officials to develop recommendations that the five-member SEC can vote on. Yellen said she fully supports the SEC’s efforts to reform the current system.

Councilors also expressed concern that the global financial system is not moving fast enough to prepare for the transition from LIBOR, the London interbank supply rate that has served as the benchmark rate for trillions of dollars in financial contracts.

The regulatory authorities have supported the switch from the LIBOR rate to the Secured Overnight Financing Rate (SOFR) by the end of this year.

However, Yellen and other officials expressed concern that not enough was being done to prepare for the move from LIBOR to SOFR.

“More needs to be done to enable an orderly transition,” Yellen told the panel. “While important advances are being made in some segments of the market, others, including corporate lending, are far behind what they should be at this stage of transition.”

Biden says U.S. will search to ‘finish most cancers as we all know it’ after Covid pandemic

president Joe Biden said Friday that once the Coronavirus pandemic Once defeated, his government will fight another deadly disease: cancer.

“I want you to know that once we defeat Covid we will do everything we can to end cancer as we know it,” Biden said in a post-tour speech Pfizers Massive coronavirus vaccine manufacturing facility in Kalamazoo, Michigan.

Cancer is the second leading cause of death in the United States National Center for Health StatisticsAlmost 1.9 million new cancer cases will be diagnosed in the US in 2021. American Cancer Society researchers appreciate it.

One of Biden’s sons, Beau Biden, died of an aggressive form of brain tumor at the age of 46.

Biden said two White House offices, the Science and Technology Advisory Council and the Science and Technology Policy Bureau, will be involved in developing an “advanced research effort into cancer and other diseases.”

Dr. Eric Lander, the director of the Broad Institute of MIT and Harvard University, will jointly lead both offices, Biden said.

The president compared the initiative to DARPA, the Pentagon agency charged with testing new technologies.

As a presidential candidate, Biden had the creation of such an agency as part of the “Made in America“Plank its platform. Its campaign website called it the Advanced Research Projects Agency for Health, or ARPA-H.

Then-candidate Biden reportedly raised the proposal frequently at fundraisers for private campaigns, though he rarely spoke about it at public events.

Biden’s forward-looking announcement seemed to send the message that his government has gotten a better grip on the pandemic.

That message was underscored by the location he intended to deliver it to: a 1,300 acre vaccine manufacturing facility where millions of doses of Pfizer’s Covid vaccine are manufactured, packaged, frozen and shipped.

“We’re now at a point where the average daily number of people vaccinated has nearly doubled since the week before I took office, to an average of 1.7 million per day,” said Biden, adding: ” We’re on track to exceed my commitment to “administer 100 million shots in his first 100 days as president”.

But “despite the progress, we are still in the teeth of a pandemic,” warned Biden.

He noted that new strains of the virus are emerging and that the U.S. is poised to soon pass the grim milestone of 500,000 deaths from Covid.

“If there is one message that needs to be given to everyone in this country, it is this: The vaccines are safe. Please take the vaccine for yourself, your family, your community, this country, when it is your turn and are available, “said Biden.

Biden urged Americans to continue taking precautions for their health and safety, including hand washing, social distancing and wearing masks.

“Look, I know it’s inconvenient, but you make a commitment when you do,” said Biden. “Everyone has to do their part for themselves, their loved ones and, yes, their country. It’s a patriotic duty.”

Appalachian Arts & Leisure Awards search to honor expertise of area | Information

The aim of the first Appalachian Arts & Entertainment Awards, which will air in March, is to highlight the diverse talent of the Appalachian region.

However, the public may have the choice of determining the winners of the competition by getting involved macarts.com on February 2nd to have a say in the selection of top performers and artists in eight categories.

Jill Hamlin, assistant director of fine arts at Mountain Arts Center, was in London last week to promote the talent competition and encourage local residents to vote for the winners in each category. It was featured in Forcht Broadcasting (SAM 103.9 FM and WNAV 96.7 FM) to explain the award program and encourage other artisans in the Appalachian region to make their selections for the event next year.

“The awards program is like the Grammys – we have musicians, dancers, singers and great hosts,” said Hamlin. “We picked the top 5 in each category and these range from the best radio DJ to the best tattoo artist.”

The top 5 finalists in each category will be announced on February 2nd and those who tune in can vote for their favorite entrant for the People’s Choice Award.

These finalists submitted their entries, with the winners being selected by popular vote. They are then put before a jury who are experts in their various fields. Judges are selected from Boston, Los Angeles, Florida, and other areas. The fields were narrowed down from 1,200 submissions. Other categories include photography, painting, sculpture, dance education, music educator, singers, authors, original songwriters, short films, radio and television personalities, high school bands and college bands. The musical selection varies from bluegrass to punk, from Americana to country and rock, gospel and reggae.

“We have categories for all types of music, art, writing, photography, music educators, and video production,” she added. “We just really want to shed light on ourselves and our heritage.”

Hamlin said the awards are a partnership between the Mountain Arts Center and the Big Sandy Community and Technical College. Tickets for the award program could be bought when visiting the Mountainartscenter or macarts.com.

“We have so much talent here and so often do we have that stigma of being uneducated and unrefined,” said Hamlin. “We want to show the talent of the people in this area – Appalachia is so often associated with Kentucky, Virginia and West Virginia, but the Appalachian Mountains actually stretch from New York to Mississippi and Alabama.”

The Appalachian Mountains actually extend into 13 states, from southern New York to Pennsylvania, to western and south Ohio, eastern Kentucky, West Virginia, eastern Virginia, central Tennessee, eastern North Carolina, and northeast South Carolina , Northern Georgia and Central Alabama and Northwest Mississippi.

“Appalachia is just one of many cultures, but the purpose of the awards – called APPYs – is to make us proud of who we are and proud of our art,” continued Hamlin. “Often times we feel we have no voice and we hope this inspires artists in the region to be proud of their legacy.”

Hamlin said the stereotype that is often imposed on people in the area is negative.

“Movies like ‘Liberation’ and ‘O brother, where are you?’ Don’t do us a favor, “she said. “The documentaries from a few years ago, where people in the area were labeled ‘Mountain Dew Mouth’, didn’t help either. We want to highlight our heritage. We have so many resources here – we make our own clothes, we do pull on our own food. If the technology were turned off, we would survive. “

This strength, she said, makes the people of this region resilient and resourceful.

“We have always taken care of each other, including our worst enemy. We would help them if they were hurt,” she added. “Appalachia nourishes the heart and soul. We are givers, we are educators and we want to emphasize who we are.”

Hamlin added that the organizers hope to expand the categories even further over the next year and encouraged artisans to submit their work. To do this, visit appalachianartsandentertainmentawards.com and fill out an online form to submit your listing. Artists can submit their work or be nominated.

For more information, visit the Mountain Arts Center at (606) 886-2623 or visit the website at macarts.com. The actual award ceremony will take place on March 20th at 7pm in the Mountain Arts Center. Tickets cost $ 25 to $ 40 each. Anyone wishing to attend events in person is asked to wear masks.

njohnson@sentinel-echo.com

Appalachian Arts & Leisure Awards search to honor expertise of area | Information

The aim of the first Appalachian Arts & Entertainment Awards, which will air in March, is to highlight the diverse talent of the Appalachian region.

However, the public may have the choice of determining the winners of the competition by getting involved macarts.com on February 2nd to have a say in the selection of top performers and artists in eight categories.

Jill Hamlin, assistant director of fine arts at Mountain Arts Center, was in London last week to promote the talent competition and encourage local residents to vote for the winners in each category. It was featured in Forcht Broadcasting (SAM 103.9 FM and WNAV 96.7 FM) to explain the award program and encourage other artisans in the Appalachian region to make their selections for the event next year.

“The awards program is like the Grammys – we have musicians, dancers, singers and great hosts,” said Hamlin. “We picked the top 5 in each category and these range from the best radio DJ to the best tattoo artist.”

The top 5 finalists in each category will be announced on February 2nd and those who tune in can vote for their favorite entrant for the People’s Choice Award.

These finalists submitted their entries, with the winners being selected by popular vote. They are then put before a jury who are experts in their various fields. Judges are selected from Boston, Los Angeles, Florida, and other areas. The fields were narrowed down from 1,200 submissions. Other categories include photography, painting, sculpture, dance education, music educator, singers, authors, original songwriters, short films, radio and television personalities, high school bands and college bands. The musical selection varies from bluegrass to punk, from Americana to country and rock, gospel and reggae.

“We have categories for all types of music, art, writing, photography, music educators, and video production,” she added. “We just really want to shed light on ourselves and our heritage.”

Hamlin said the awards are a partnership between the Mountain Arts Center and the Big Sandy Community and Technical College. Tickets for the award program could be bought when visiting the Mountainartscenter or macarts.com.

“We have so much talent here and so often do we have that stigma of being uneducated and unrefined,” said Hamlin. “We want to show the talent of the people in this area – Appalachia is so often associated with Kentucky, Virginia and West Virginia, but the Appalachian Mountains actually stretch from New York to Mississippi and Alabama.”

The Appalachian Mountains actually extend into 13 states, from southern New York to Pennsylvania, to western and south Ohio, eastern Kentucky, West Virginia, eastern Virginia, central Tennessee, eastern North Carolina, and northeast South Carolina , Northern Georgia and Central Alabama and Northwest Mississippi.

“Appalachia is just one of many cultures, but the purpose of the awards – called APPYs – is to make us proud of who we are and proud of our art,” continued Hamlin. “Often times we feel we have no voice and we hope this inspires artists in the region to be proud of their legacy.”

Hamlin said the stereotype that is often imposed on people in the area is negative.

“Movies like ‘Liberation’ and ‘O brother, where are you?’ Don’t do us a favor, “she said. “The documentaries from a few years ago, where people in the area were labeled ‘Mountain Dew Mouth’, didn’t help either. We want to highlight our heritage. We have so many resources here – we make our own clothes, we do pull on our own food. If the technology were turned off, we would survive. “

This strength, she said, makes the people of this region resilient and resourceful.

“We have always taken care of each other, including our worst enemy. We would help them if they were hurt,” she added. “Appalachia nourishes the heart and soul. We are givers, we are educators and we want to emphasize who we are.”

Hamlin added that the organizers hope to expand the categories even further over the next year and encouraged artisans to submit their work. To do this, visit appalachianartsandentertainmentawards.com and fill out an online form to submit your listing. Artists can submit their work or be nominated.

For more information, visit the Mountain Arts Center at (606) 886-2623 or visit the website at macarts.com. The actual award ceremony will take place on March 20th at 7pm in the Mountain Arts Center. Tickets cost $ 25 to $ 40 each. Anyone wishing to attend events in person is asked to wear masks.

njohnson@sentinel-echo.com