Pfizer said Friday that its easy-to-use Covid-19 pill, used in combination with a widely used HIV drug, increased the risk of hospitalization or death in high-risk adults exposed to the virus by 89% lowers.
It’s now the second antiviral pill behind it Merck‘s to demonstrate strong efficacy in treating Covid at the first sign of disease. If approved by regulators, it would likely mark a turning point in the ongoing global battle against the pandemic.
Pfizer CEO Albert Bourla told CNBC the company plans to submit its data to the Food and Drug Administration before Thanksgiving.
“I think this drug is going to change the way things are happening, that are going to save millions and millions of lives, it has the potential to do that,” Bourla said in an interview with CNBC.Squawk box“He said the company has” the current capacity of 500 million pills, “which in his opinion equates to 50 million treatments.” The very high level of effectiveness comes as a surprise even to us and exceeds our most visionary expectations about it. “
Pfizer’s pill, scientifically known as PF-07321332, belongs to a class of drugs called protease inhibitors and works by blocking an enzyme that the virus needs to multiply in human cells. Protease inhibitors are used to treat other viral pathogens such as HIV and hepatitis C.
The HIV drug helps slow the metabolism or breakdown of the Pfizer pill so that it stays active in the body for longer periods of time at higher concentrations, the company said.
The company said its data on the drug is based on a mid-to late-stage study of 1,219 adults who had at least one underlying disease and one laboratory-confirmed infection within five days. Participants also received a low dose of ritonavir, a drug often used in combination treatments for HIV.
Pfizer said there were six hospitalizations and zero deaths of the 607 study participants who received the pill in combination with the HIV drug within five days of the onset of symptoms. That compares to 41 hospitalizations and 10 deaths for the 612 people who received a placebo.
“These data suggest that our oral antiviral candidate, if approved by regulators, has the potential to save patients’ lives, reduce the severity of COVID-19 infections and achieve up to nine out of ten hospital stays Avoid, “said Albert Bourla, CEO of Pfizer in a statement.
not how Gilead SciencesThe intravenous drug Remdesivir, Pfizer and Merck drugs can be taken orally. While vaccinations remain the best form of protection against the virus, health experts hope pills like these will prevent the progression of the disease in those who become infected and prevent hospitalizations.
Biotherapeutics from Merck and Ridgeback said on October 1st that they developed a drug that, when given on its own, reduces the risk of hospitalization or death in patients with mild or moderate cases of Covid by about 50%.
Merck’s antiviral pill was approved by The UK Medicines Agency on Thursday.
June Raine, chief executive of the UK’s drug and health products regulator, said the Merck pill is the treatment of Covid, a disease that has cost the lives of more than 5 million people worldwide and has put an enormous strain on health systems.
Bourla told CNBC in April that Pfizer’s pill could be available to Americans by the end of this year.